Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) MIA3 Polyclonal antibody

Uniprot No.

Q5JRA6

Target Names

MIA3

Alternative Names

ARNT antibody; C219 reactive peptide antibody; C219-reactive peptide antibody; D320 antibody; Melanoma inhibitory activity family; member 3 antibody; Melanoma inhibitory activity protein 3 antibody; Mia3 antibody; MIA3_HUMAN antibody; RP11-378J18.4 antibody; TANGO antibody; Transport and Golgi organization protein 1 antibody; UNQ6077 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Transport and Golgi organization protein 1 homolog protein (1447-1626AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Biotin

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Target Background

Function

Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1. It is also specifically required for the secretion of lipoproteins by participating in their export from the endoplasmic reticulum. Required for correct assembly of COPII coat components at endoplasmic reticulum exit sites (ERES) and for the localization of SEC16A and membrane-bound ER-resident complexes consisting of MIA2 and PREB/SEC12 to ERES.

Gene References into Functions

ADTRP positively regulates PIK3R3 expression, which leads to activation of AKT and up-regulation of MIA3/TANGO1, thereby regulating endothelial cell functions directly relevant to atherosclerosis. PMID: 28341552
TANGO1/CTAGE5 receptor serves as a polyvalent template for assembly of large COPII coats. PMID: 27551091
Mammalian endoplasmic reticulum exit sites are organized by TANGO1 acting as a scaffold, in cooperation with Sec16 for efficient secretion. PMID: 28442536
TANGO1 is thus pivotal in concentrating procollagen VII in the lumen and recruiting ERGIC membranes on the cytoplasmic surface of the endoplasmic reticulum. PMID: 26568311
TANGO expression was strongly associated with tumour progression, nodal metastasis, clinical stage and number of blood or lymph vessels in oral squamous cell carcinoma. PMID: 24889917
We conclude that SNP rs17465637 in MIA3 is indeed a genetic risk factor for CAD across different ethnic populations including Han Chinese. PMID: 24125424
results suggest a potential association of the MIA3 rs17465637 with cardiovascular disease in dyslipidemic patients with rheumatoid arthritis PMID: 22577832
genetic polymorphism is associated with an increased risk of myocardial infarction PMID: 21264445
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) PMID: 20738937
Observational study of gene-disease association. (HuGE Navigator) PMID: 20971364
Observational study of gene-disease association. (HuGE Navigator) PMID: 20694560
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
TANGO transfected cell lines revealed that TANGO expression reduces motility, whereas reduction of TANGO enhances migration. PMID: 17044017
The results from this study present TANGO as a novel ligand for CD11c, regulating migratory processes of hematopoietic cells. PMID: 17726152
Reduced expression of TANGO is associated with colon and hepatocellular carcinomas PMID: 17786351
Observational study of gene-disease association. (HuGE Navigator) PMID: 19955471
Observational study of gene-disease association. (HuGE Navigator) PMID: 19336575
Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 19198609

Hide All

Subcellular Location

Endoplasmic reticulum membrane; Single-pass membrane protein.

Protein Families

MIA/OTOR family, Tango1 subfamily

Tissue Specificity

Broadly expressed, except in bone marrow and peripheral blood mononuclear cells. Down-regulated in melanoma tissue.

Database Links

HGNC: 24008

OMIM: 613455

KEGG: hsa:375056

STRING: 9606.ENSP00000340900

UniGene: Hs.118474

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Code	CSB-PA711448LD01HU
Size	US$166
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MIA3 Antibody, Biotin conjugated

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Target Background